From molecular assembly to cancer dependency

Transcription is not a single switch. It is an assembled system in which DNA-bound factors, cofactors, chromatin regulators, RNA polymerase and RNA-modifying machinery cooperate to determine which genes are expressed, at what strength and in what molecular form. The laboratory resolves these dependencies in breast cancer and glioblastoma to expose vulnerabilities that can be targeted more precisely.

Cofactor cooperativity and BET-inhibitor resistance

We define how BRD4, Mediator and elongation machinery sustain oncogenic transcription when bromodomain inhibition fails.

Therapy-induced senescence and adaptive transcription

We investigate how tumour cells enter, maintain or escape therapy-induced senescence through transcription-factor and cofactor control.

RNA modification in glioblastoma stemness

We study how m6A writing, erasure and recognition shape self-renewal, proliferation and invasive growth in glioblastoma stem-like cells.

Signalling–chromatin–transcription circuits in cancer

We trace how extracellular signals are converted through chromatin regulators and transcription factors into durable malignant programmes.