Molecular mechanisms of the MLL4 complex in H3K4 methylation and p53-dependent transcription activation
Molecular Cell
LabNarrative concept · prepared as an independent design proposal
Publications
Recent and defining work
Selected research outputs that define the laboratory’s scientific direction and emerging programme.
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Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity
Nature Structural & Molecular Biology
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
Nature Communications
Aberrant Activation of β-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2
Cancer Research
Mechanism of N6-methyladenosine modification and its emerging role in cancer
Pharmacology & Therapeutics
m6A Demethylase ALKBH5 Maintains the Tumorigenicity of Glioblastoma Stem-Like Cells by Sustaining FOXM1 Expression
Cancer Cell
Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1
EMBO Reports
FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes Glioblastoma Stem-like Cells
Cancer Research